Climbing fibres recruit disinhibition to enhance Purkinje cell calcium signals

Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10220-4 Synchronous activation of climbing fibres engages disinhibitory circuitry to promote large dendritic calcium signals in Purkinje cells that are necessary to promote cerebellar learning.

• Seeking an industry role? Sell yourself as a problem-solver, not a job-seeker
  Nature News
• Masked mitochondria slip into cells to treat disease in mice
  Nature News
• Mathematician who reshaped number theory wins prestigious Abel prize
  Nature News
• Botanical mystery solved: how plants make a crucial malaria drug
  Nature News
• Catabolism of extracellular glutathione supplies cysteine to support tumours
  Nature News
• A strong constraint on radiative forcing of well-mixed greenhouse gases
  Nature News
• Climbing fibres recruit disinhibition to enhance Purkinje cell calcium signals
  Nature News
• Adventitious carbon breaks symmetry in oxide contact electrification
  Nature News
• Integrated photonic neural network with on-chip backpropagation training
  Nature News
• Biosynthesis of cinchona alkaloids
  Nature News

• Publisher Correction: Atlas-guided discovery of transcription factors for T cell programming 51.0%
• Nigeria’s Osimhen tried to defy broken arm in Galatasaray loss at Liverpool 71.0%
• Follow live: Miami (OH), SMU face off in First Four 66.0%
• Luka Doncic scores 40 points as Lakers defeat Rockets in NBA 61.0%
• Major Turing computing award goes to quantum science for first time 59.0%